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A simplified loss assessment methodology taking into account regional-based design practice is described herein. Typical obsolete (between 1960 and 1980) design practice for reinforced concrete (RC) structures in Mediterranean countries is herein considered. In particular, a 4-story RC moment resisting frame (MRF) is designed according to obsolete seismic Italian design provisions, resulting in a structure characterized by typical features of the building stock of the area struck by the 2009 L’Aquila earthquake. For the same design, two different executive hypotheses are considered, resulting in two non-ductile RC structural configurations dominated by two different failure modes of primary elements, i.e., flexure-shear- and shear- dominated. A simplified loss estimation methodology, including a site-specific hazard analysis, a pushover-based approach for seismic demand assessment, and a simplified damage and cost analyses focused on the RC columns, is employed to evaluate the risk of earthquake economic losses and the influence of structural design decisions on such losses.